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Gastrointestinal side effects are the most commonly reported adverse reactions with GLP-1 receptor agonist weight loss injections, occurring in a substantial proportion of users

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[1] [2] Blood pressure generally decreased in trial participants, likely reflecting the effects of weight loss

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Further changes in BBB integrity have been noted with changes in expression and function of BBB transporters and receptors such as GLUT1, LRP, or Pgp [103,104,105,106,107,108,109,110,111]

Additionally, it inhibits the production of glucagon, the hormone that increases glycogenolysis (release of stored carbohydrate from the liver) and gluconeogenesis (synthesis of new glucose)