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Metformin attenuates hypothalamic inflammation via downregulation of RIPK1-independent microglial necroptosis in diet-induced obese mice

In the randomized, double-blind, placebo-controlled phase 2 EMBRAZE study, adults with overweight or obesity ( n = 102) were randomized 1:1 to receive tirzepatide plus apitegromab (10 mg kg 1 ) or tirzepatide plus placebo

Escalating too quickly increases nausea, reflux, and discontinuation risk

We do see a slight pullback in the overall basket, just less units, slightly less calories

Results showed that liraglutide-treated patients achieved significantly greater weight loss compared to placebo over 24 weeks

Skibicka, K