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Waters Acquity UPLC BEH C18 1.7 m 2.1 50 mm chromatographic column was used, at 40 C, 0.3 mL/min flow rate, and 1.0 L of injection volume (the samples were dissolved in LCMS grade acetonitrile, typically at a concentration of 0.11 mg/mL prior to injection)
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In T2DM patients, the average change in HbA1c was 2.1% with a dose of 45 mg of orforglipron (compared to dulaglutide and placebo), and nearly half of the participants achieved more than a 10% reduction in body weight in a 26-week phase 2 trial [108]
She says the administration is bypassing normal research and safety checks with leucovorin
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