Most medical and experimental protocols emphasize a conservative, progressive approach, beginning with minimal exposure to assess tolerance and biological response
Little degradation (apparent t1/2 about 10 h) of DSIP to major metabolites, tryptophan (trp) and des-trp DSIP, occurred over the time of the diffusion experiments
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de Jong SC, Stehouwer CD, van den Berg M, Kostense PJ, Alders D, Jakobs C, Pals G, and Rauwerda JA (1999b)
The treatment involved intravenous DSIP administration on five consecutive days, followed by five injections every 48-72 hours