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10.1074/jbc.274.42.30101 115 GaoL.ChalupskyK.StefaniE.CaiH

The risk of amputation was highest in patients with a baseline history of diabetic foot, peripheral artery disease (including previous amputation) or diabetes

Cytosolic Ca 2+ entering the mitochondrial matrix through the mitochondrial Ca 2+ uniporter (MCU) stimulates OXPHOS by activating pyruvate dehydrogenase phosphatase, which in turn, increases the activity of pyruvate dehydrogenase complex [21]

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10 Conclusion and future perspectives The immunometabolic crosstalk between tumor-associated macrophages (TAMs) and ferroptotic cancer cells has emerged as a defining regulator of tumor fate, influencing progression, metastasis, immune evasion, and therapeutic response