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Activity-balanced GLP-1/GDF15 dual agonist reduces body weight and metabolic disorder in mice and non-human primates

When including all treated participantsthose who completed the trial and those who discontinuedweight loss averaged 23.7%: still substantial, but meaningfully lower than the 28.7% efficacy headline

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GIP also appears to reduce the nausea commonly associated with pure GLP-1 agonists

People taking GLP-1 drugs like those being prescribed Ozempic were 66% more likely to be diagnosed with gastroparesis, with 0.53% of patients diagnosed about 750 out of nearly 150,000 patients

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