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A study that uses MT-II for a pigmentation endpoint may need to account for central, autonomic, appetite, sexual-function, or behavioural confounders depending on model and exposure

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Large-scale human studies and meta-analyses have largely been reassuring, showing no clear evidence of a significant increase in MTC risk for the general population

To achieve the best outcomes, this may involve a combination of medicine, diet, exercise, and other lifestyle changes

Gastroenterol., 19: 5633-5644

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