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Zhao M, Wang S, Zuo A et al (2021) HIF-1/JMJD1A signaling regulates inflammation and oxidative stress following hyperglycemia and hypoxia-induced vascular cell injury

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These reactive oxygen species may subsequently interact with superoxide dismutase and glutathione, leading to reduced levels of these antioxidants, making the brains ability to cope with oxidative stress damage much reduced and further accelerating neuronal cell damage in the corresponding brain regions ( The glutamate hypothesis of schizophrenia suggests that the function of N-methyl-D-aspartate (NMDA) receptors is impaired in this disorder