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However, high-grade dysplasia can regress to low-grade dysplasia if reflux injury is present and creating a red herring

[DOI] [PubMed] [Google Scholar] 14.Moghaddas A, Dashti-Khavidaki S

Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia

Common methods include radiolabeling (attaching a detectable isotope to the compound and tracking its distribution via imaging), microdialysis (sampling interstitial fluid directly from brain tissue), and post-mortem tissue analysis measuring compound concentrations in specific brain regions

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Neuropharmacology 61: 592-599