New research shows GLP-1 drugs can help reduce pain and improve mobility, sometimes more than SGLT2 inhibitors
GLP-1 peptides fail on all three counts
Most of the evidence supporting their impact is derived from research conducted on rats or other animal subjects, rather than from rigorous human trials
doi: 10.1038/s41598-019-52103-x 12 AbdalqadirNAdeliK
GLP-1s and Addiction The authors of GLP-1 Therapeutics and Their Emerging Role in Alcohol and Substance Use Disorders: An Endocrinology Primer , appearing in October 2025 in JES, point out that the World Health Organization reported 890 million adults and 60 million children and adolescents had obesity in 2022 globally
A long-acting release form of exenatide (exenatide ER, Bydureon) was approved by the FDA in 2012, becoming the first once-weekly injection of a GLP-1RA for adults with T2DM [ Table 2 ]