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In people with overweight/obesity and non-diabetic CKD who were included in the SMART study, 2.4 mg semaglutide once weekly versus placebo reduced UACR by 52% at 24 weeks of treatment (87)
Ongoing Research and Expansion Pharmaceutical companies continue researching new uses for GLP-1 medications, including potential benefits for cardiovascular health and other chronic conditions
S2CID 29733898
The mechanistic explanation is not speculative: the glucagon receptor adds hepatic fatty-acid oxidation, adipose lipolysis and thermogenic energy expenditure that dual agonism cannot engage by design 27, and the Phase 2a MASLD readouts 8590% liver-fat reduction is a direct signature of that pathway 3
The side effect data is clear on this point
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