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They serve different purposes.

Sodium aescinate provides neuroprotection in experimental traumatic brain injury via the Nrf2-ARE pathway

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demonstrated that the sulfated polysaccharide SU1F1 from green algae exhibits potent anti-HSV activity, particularly against HSV-1, with efficacy increasing alongside the degree of sulfation [111]

Aggregation or precipitation in solution, reducing available monomeric peptide