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Impaired NO synthesis or increased NO degradation due to oxidative stress reduces vasodilatory capacity, promotes vasoconstriction, and enhances vascular tone, contributing to hypertension and ischemia (36, 37)

As research into the drugs efficacy and side effects deepens, as drug costs gradually decrease, and personalized treatment plans are further optimized, GLP-1 RAs are likely to become a routine treatment choice for this patient population in the future

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However, mutations in FGF-21 receptors, including FGFR1 and KLB, impair FGF-21 signaling, reducing GLUT-1 and GLUT-4 mediated glucose uptake, which exacerbates IR

10.1186/s12868-017-0387-7 BMC Neurosci