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For long-term use spanning more than one year, 12 weeks on followed by 8 weeks off is the advised structure to minimize cumulative receptor desensitization
However, these trials are still ongoing and currently, semaglutide is in phase 3
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In addition, because the tissues in which the GLP-1 receptor is expressed are not limited to the gastrointestinal and pancreatic glands, GLP-1RA can reduce cardiovascular risk in addition to lowering glucose and reducing body weight
Setting Realistic Goals Its important to have realistic expectations when using semaglutide for weight loss
If cold sensitivity becomes problematic, PlexusDx also offers oral semaglutide ($289/mo) or the Microdose GLP-1 Protocol ($129/mo flat), which some patients tolerate with fewer temperature-related side effects
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