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In summary, both GIP and GLP-1 mediate the incretin effect but there is continuing emerging evidence that these hormones modulate physiological responses in extrapancreatic organs

[#3] clue to diagnosis: brown blood Methemoglobinemia may cause chocolate-brown discoloration of the blood

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One study has also identified the liver, skeletal muscle and adipose tissue as additional GLP-1 targets (39), further highlighting its diverse and significant biological functions

ZBP1 promotes hepatocyte pyroptosis in acute liver injury by regulating the PGAM5/ROS pathway

37 CuiJ.WangW.TangY.FengS.LiuH.HaoZ