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Consequently, the skin remains loose and saggy, particularly in areas with significant fat deposits, such as the upper arms

10.1038/s41579-020-0433-9 Nat

Therefore, to safely harness the attractive catabolic and thermogenic effects of glucagon for treating metabolic disease, a counter-balancing therapy that selectively opposes the risk for glucagon-induced hyperglycaemia is required

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PMID: 15931262

On a subsequent day, a glucose infusion is given, the rate of which is adjusted manually to copy the excursions from the oral day