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This paradigm explains the high prevalence of OA in non-weight-bearing joints (e.g., hands) among obese individuals, a finding that cannot be attributed to mechanical load alone

First, as your body adjusts to lower blood sugar levels and a different metabolic pace, your energy expenditure may shift

Frank et al., 2014), however, these properties cannot be taken full advantage of because estrogen also acts as a carcinogen (Huang et al., 2014)

doi: 10.1007/s40265-018-0871-0 [DOI] [PubMed] [Google Scholar] 22.Weiss T, Yang L, Carr RD, et al

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