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Pfizer - Partnership (December 2025): Pfizer struck a $2 billion deal with YaoPharma to develop and commercialize a phase 1 small-molecule GLP-1 receptor agonist [1]

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did not find any sex-dependent effects in mice or humans, in contrast to their previous report for the -opioid system

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3 These rates appear higher than those seen with the injection, which may reflect the daily dosing pattern compared with once-weekly injections

Additionally, Rh4 elevated ROS accumulation, which activatedROS/p53 signaling pathway, thus demonstrating that Rh4 inhibits proliferation of cancer cell via promoting the ROS/p53 signaling pathway and inducing ferroptosis through autophagy (75)