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However, due to its short circulating half-life, native GLP-1 is ill-suited for chronic therapy [14]

Glucagon-like peptide (GLP)-1 regulation of lipid and lipoprotein metabolism

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Zepbound has a list price of $1,086.37 , and its single-use vials have a cash price $299$449 per month, depending on dose

GLP-1 medications can help manage type 2 diabetes and obesity, but they may cause short-term mild-to-moderate side effects such as nausea, vomiting, diarrhoea, constipation, bloating, and decreased appetite, particularly at the beginning of treatment

Bone 53 , 382390 (2013)