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Gastrointestinal Side Effects : Restarting the medication after a long break may result in adverse gastrointestinal side effects such as nausea or diarrhea, especially if returning to a higher dose too quickly

The cardiovascular community, expecting the usual incremental class effect, instead got the SELECT trial, a 20% reduction in major adverse cardiovascular events in patients with overweight or obesity and established cardiovascular disease, in patients without diabetes