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While there is growing interest in this area, much of the research is still in its early stages

The animals were placed under the light beam of a fluorescence microscope (Zeiss model AXIO SCOPE A1, Obercochen, Germany), and microcirculation images were acquired using Zen Blue software (Zeiss, Obercochen, Germany)

All three studied doses (4 mg, 9 mg, and 12 mg) met the primary and key secondary endpoints

Most patients tolerate tirzepatide well, though nausea, vomiting, and constipation occur during dose escalation in roughly 3040% of users and typically resolve within 12 weeks