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"Five missense mutations in glucagon-like peptide 1 receptor gene in Japanese population"

These observations support the hypothesis that GLP-1RAs may exert anti-inflammatory effects partly through the restoration of insulin responsiveness, rather than through weight reduction alone

doi: 10.1111/dom.13030

Glucagon is often thought of only as the hormone that raises blood sugar, but at the level of the liver and metabolically active tissues it also increases energy expenditure, promotes the breakdown of stored fat, and reduces hepatic fat content

Transition to the glucagon-bound state requires the lid-like -sheet module to undergo a major conformational change