I., Fischbarg, J
10.1038/s41467-019-13014-7 Nat Commun
The paraventricular nucleus integrates these signals and coordinates downstream responses including reduced food intake
DRUG INTERACTIONS As with other medications, topiramate can interact with alcohol, marijuana and certain medications, including antiepileptic drugs, CNS depressants, oral contraceptives, lithium, other carbonic anhydrase inhibitors, hydrochlorothiazide, pioglitazone and amitriptyline
As well, in real-world scenarios, such as described by Brindisi et al, it is mentioned a reduction in pleasure and taste perception in overweight and people with obesity with poor type 2 diabetes control, probably by lowering the detection threshold of sweet flavors, becoming more sensitive to them, resulting in aversion for this flavor (175)
Our experience working with research facilities shows that the most common storage error is not the initial refrigeration decision