novo oral glp-1 The challenge of developing alternatives to Ozempic, Wegovy and Mounjaro Novo's Rybelsus gains FDA expansion

[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Caruso I, Di Gioia L, Di Molfetta S, et al

CJC-1295 is a Growth Hormone Releasing Hormone (GHRH) analog, and Ipamorelin is a Ghrelin mimetic, or a Growth Hormone Secretagogue (GHS)

Sule K, Umbsaar J, Prenner EJ

Positive AMPA receptor modulation rapidly stimulates BDNF release and increases dendritic mRNA translation

Instead, I'd like to focus on understanding GLP-1s (what they do and what they dont do) and also: understanding what your body is already capable of and exploring how to work with your natural biology first, not against it

Currently, the approved GLP-1 agonists in the UK mimic GLP-1 (Wegovy and liraglutide), or both GLP-1 and GIP (Mounjaro)