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Clinician-led dose adjustments of existing diabetes medicines may be required

Additionally, factors such as food intake, timing, and hydration can affect how well the medication is absorbed

When GLP-1s were in shortage, platforms like Hims & Hers and Ro distinguished themselves by offering compounded GLP-1s at significant discounts, but these unregulated copycat drugs have largely been phased out after the Food and Drug Administration (FDA) declared the shortage over in late 2024 and gradually ramped up enforcement

Current Availability and Regulatory Status in the UK Retatrutide is not approved by the MHRA and cannot be legally prescribed in the UK outside of an approved clinical trial

The development of Tirzepatide represents a significant advancement in diabetes therapeutics due to its unique mechanism of action and potential clinical benefits

Ideal candidates include adults with a BMI over 27 (with a weight-related condition) or over 30, who are looking for support with sustainable weight loss and have not had success with diet and exercise alone