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Reduced appetite: GLP-1 medications can result in a lack of interest in food, potentially leading to undereating, causing nutrient deficiencies and potential muscle loss

Real-World Evidence A study published in JAMA Internal Medicine analyzed 18,386 adults who are overweight or with obesity in real-world clinical settings

doi:10.1007/s00592-025-02468-5 Su B, Sheng H, Zhang M, et al

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(2018) 123:e3547

Retatrutide-assisted recomposition offers advantages for recreational lifters who want to stay lean year-round, individuals who respond poorly to cutting phases (excessive muscle loss or metabolic adaptation), those who struggle with appetite control and binge eating tendencies, and older lifters where aggressive weight fluctuations may be less advisable