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proposed that polyphenols activate NRF2 in astrocytes through the production of H 2 O 2 , semiquinones, and quinones

first described ferroptosis (Table 1

Cell proliferation assays Proliferation assay was performed as previously described [8]

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Since inhalation of toxic fumes is a major route of Mn overexposure in humans, intranasal delivery of Mn is widely used as an in vivo inhalation exposure model in research and has been shown to alter neurotransmitter levels, induce neuroinflammation, and impair behavior in mice (Moberly et al., 2012