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There are no human studies on sublingual tirzepatide, and compounded formulations lack the absorption technology found in FDA-approved medications

The FDA has warned about dosing errors with compounded injectable semaglutide, including cases where patients required medical attention or hospitalization

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doi: 10.1186/s40001-022-00833-6 102 HouM.ChenF.HeY.TanZ.HanX.ShiY.et al

If those sensations gradually become less noticeable, some may incorrectly assume the medication is no longer effective. "Our results suggest that patients may experience a partial return of appetite sensations over time, without losing the medication's benefit of continuing to reduce calorie intake, which is needed to maintain their new, lower body weight," Tronieri said