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Krogh et al

Magnes Res

This, together with the discovery of high-affinity binding sites for [ 125 I]Ang IV in the central nervous, vascular and renal systems, 16, 116, 117 has led to the concept of a novel Ang receptor subtype: the AT 4 receptor, 14 which was convincingly shown to be insulin-regulated aminopeptidase (IRAP), a membrane-anchored zinc-dependent metallopeptidase

Alternatively, the otic gel formulation is applied via syringe and needle, wherein the needle is inserted through the tympanic membrane and guided to the area of the round window or crista fenestrae cochleae