doi: 10.3390/ijms20030642
the National Institutes of Health (NIH) recently funded La Jolla Institute for Immunology (LJI) in this endeavour 68
Hesperidin can regulate lipid metabolism (upregulating PPAR, CPT1, ACOX1, and ACADM, downregulating HADH, SREBP-1C, and SCD1) and the gut microbiota (mainly increasing the Bacteroidetes / Firmicutes ratio), participating in the regulation of lipid metabolism ( Firmicutes / Bacteroidetes ratio and the abundance of Bacteroidetes and Lactobacillus ) ( In summary, the research found that botanical drugs and their active metabolites can participate in regulating the gut microbiota and SCFAs levels, improving bile acid metabolism, modulating related hormones of the BGA, and regulating inflammatory factors
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Half of the studies reported a reduction in the risk of the composite outcome, similar to the add-on therapy or simultaneous use of the medications
Arutjunyan A, Kozina L, Stvolinskiy S et al (2012) Pinealon protects the rat offspring from prenatal hyperhomocysteinemia
