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Change in body weight from baseline was dose-dependent, and at 1.2 mg was 7.5% at day 36 (one week after the final dose), consistent with or better than marketed and clinical-stage GLP-1 / GIP compounds

Motivation and research question Cities contribute 70% of total greenhouse gas emissions (IPCC, 2022), with the heat sector as a major, hard-to-decarbonize contributor

Ma L, Peng S, Wei J, Zhao M, Ahmad KA, Chen J et al (2021) Spinal microglial -endorphin signaling mediates IL-10 and exenatide-induced inhibition of synaptic plasticity in neuropathic pain

This marks the next phase of competition in the GLP-1 space, after injectable therapies like Zepbound and Mounjaro generated more than $36B in sales for Lilly last year

If bruising is severe, extremely painful, or occurs repeatedly, contact your PlexusDx providerthey may recommend switching injection sites temporarily

doi: 10.1016/j.clnu.2021.11.014 [DOI] [PubMed] [Google Scholar] 33