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The limited absorption of the nasal cavity restricts the amount of drug being effectively absorbed, making class I drugs (high permeability, high solubility), according to the Biopharmaceutics Drug Disposition Classification System (BDDCS), particularly suitable for nasal delivery (Ugwoke et al., 2001)

Methods Mol Biol 926:8797

Suggested guidelines for the diagnosis and management of urea cycle disorders: First revision

The injectable form is typically administered once a week, while the oral form can be taken daily

Pharmacological management options: According to the American College of Gastroenterology (ACG) guidelines, an 8-week trial of once-daily proton pump inhibitors (PPIs) such as omeprazole or esomeprazole is recommended as first-line therapy for typical reflux symptoms without alarm features