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51 A meta-analysis study reported that elevated TMAO levels were significantly associated with the risk of hypertension in a dose-dependent manner

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The MTHFR gene is located on chromosome 1p36.22 and is composed of 13 exons that generate three alternatively spliced mRNAs, each of which encode distinct protein isoforms

Histamine intolerance supplements Vitamin C supplementation has also been shown to reduce histamine levels (ref), while B6 supplementation is also beneficial as it acts as a co-factor in DAO production (ref)