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Its exceptional structural stability, retained activity in gastric juice for over 24 hours, tolerance across pH 1-11, derives from its high proline content and absence of cleavage-prone motifs in the 15-residue sequence

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The data distribution was assessed using Anderson-Darling, DAgostino & Person, Shapiro-Wilk, and Kolmogorov-Smirnov tests

Since its development, AOD-9604 has been the subject of over 16 peer-reviewed publications spanning three decades, including six randomized, double-blind, placebo-controlled human clinical trials involving more than 900 participants