Foods rich in fermentable fibre include : Oats, barley, and whole grains Legumes such as lentils, chickpeas, and beans Vegetables including artichokes, Brussels sprouts, and onions Fruits such as apples, pears, and berries Healthy fats, particularly long-chain fatty acids, also stimulate GLP-1 secretion through specific receptors on intestinal L-cells
doi: 10.1038/nchembio0707-360 98
Key differences between cagrilintide and semaglutide Mechanism: Cagrilintide: Amylin receptor agonist Semaglutide: GLP-1 receptor agonist Different pathways, complementary effects Gastric emptying: Cagrilintide: Very strong effect (dramatic slowing) Semaglutide: Moderate effect Combined: Maximum slowing Appetite suppression: Cagrilintide: Works via amylin/calcitonin receptors Semaglutide: Works via GLP-1 receptors in brain Combined: Dual-pathway suppression Side effects: Cagrilintide: More nausea/GI effects (stronger gastric slowing) Semaglutide: Moderate GI effects Combined: Higher side effect risk but manageable Approval status: Cagrilintide: Investigational (not approved) Semaglutide: FDA approved CagriSema combination: Phase 3 trials Weight loss monotherapy: Cagrilintide alone: 10-12% body weight loss Semaglutide alone: 10-15% body weight loss Combined: 15-25% body weight loss Why combining cagrilintide and semaglutide works synergistically The combination targets weight loss through multiple pathways
PlexusDx also offers the Precision Peptide Genetic Test ($99 add-on after your first month of treatment), which maps 14 metabolic pathways and analyzes key variants like GLP1R rs6923761 and FTO rs9939609
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For all their promise, GLP-1 and dual GIP/GLP-1 receptor agonists have raised more questions, particularly regarding their long-term safety implications
