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Administration: Taken as a once-weekly injection under the skin

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It is generally accepted that folate supplementation is safe, but higher doses, such as the 5 mg can potentially cause adverse gastrointestinal effects, such as abdominal cramps, nausea and diarrhea, sleep disorders, irritability, rash, and lower seizure thresholds in patient taking anticonvulsants

This approach may include the use of calcium channel blockers like nifedipine (Procardia) and alpha-blockers like tamsulosin (Flomax) for four to six weeks (Antonelli 2015)

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Best Practices for Morning Intake : Take glutathione first thing in the morning, ideally 30 minutes before breakfast