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Diabetes 61 , 364371 (2012)

Bad News: Tolerability and Dropout Rates One of the biggest drawbacks has been the gastrointestinal distress caused by a GLP-1/glucagon dual agonist

However, these medications may not be suitable if you: Have a history of thyroid cancer or pancreatitis Are currently pregnant or breastfeeding Have severe digestive issues like gastroparesis GLP-1s and Metabolism: Why Theyre Different from Other Weight Loss Drugs and Lower Blood Sugar Levels Many weight loss drugs work by increasing metabolism artificially, leading to potential issues like heart palpitations, anxiety, or dependency

In February 2026, OptumRx removed the BMI threshold from its cardiovascular reauthorization criteria