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Holtzman et al., 2016)

The available window for an agonist to produce a measurable increase is compressed, because half the signal is already spent, so a genuine agonist effect can look smaller than it is

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If more than five days have passed, skip the missed dose and resume the regular dosing schedule without doubling up

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In addition to inducing epithelia hyperplasia in rabbits, PGN has been shown to induce colorectal tumors in rats