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A smaller subset of patients report that semaglutides appetite suppression and the resulting reduction in food-seeking behavior actually makes their ADHD feel more apparent, not because symptoms worsen, but because food was serving as a stimulating activity that occupied the ADHD brain, and without it, the restlessness and distractibility become more noticeable

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In Alzheimers disease, PHGDH upregulation, an upstream control point in the serine synthesis pathway, supports the idea that disrupted serine metabolism is coupled to persistent neuroinflammatory signaling 73

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