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Hyaluronic Acid (HA) for Knee Osteoarthritis Hyaluronic acid (HA) is a commonly used injection for knee OA, but recent studies suggest that PRP may offer superior and longer-lasting benefits : A meta-analysis of 14 RCTs (n = 1423 patients) found that PRP was significantly more effective than HA in reducing pain and improving function in knee OA (PMID: 29601043)