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GLP-1RA has been placed prominently in the international recommendations for the treatment of T2D as the first injectable agent before insulin due to the advantageous outcomes in cardiovascular safety studies that demonstrated a reduction of the combined cardiovascular endpoint three-component major adverse cardiovascular event (MACE-3

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APP: -amyloid precursor protein, A: Amyloid protein, BACE1: beta site APP cleaving enzyme 1, EX-4: exendin-4

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