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Perroud, T.D., Kaiser, J.N., Sy, J.C., Lane, T.W., Branda, C.S
Extracellular glutamate levels, which can counteract xCT-mediated cystine uptake, were enriched in the TIF compared to serum (Extended Data Fig
Prior studies in cancer cell lines showed that ABHD11 deficiency leads to 2-OG accumulation, which drives the formation of the l-enantiomeric ( S) form of 2-hydroxyglutarate (2-HG) and subsequent inactivation of 2-OGDDs involved in the HIF pathway (prolyl hydroxylases, PHDs), histone marks (for example, lysine demethylases, KDMs) and DNA methylation (for example, ten-eleven translocation,TET enzymes) 16,22,23
If parents have a child with Wilsons disease, they could potentially have other children with the condition as well
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Because vitamin (especially folate) supplementation can efficiently reduce plasma homocysteine levels, further prospective cohort studies and ongoing, randomized, placebo-controlled trials will determine the efficiency of folate supplementation, possibly in combination with vitamins B 12 and B 6 , in the prevention and correction of vascular disorders related to moderate hyperhomocysteinemia
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