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doi: 10.1016/j.drudis.2007.08.010

Therapeutic Rationale Behind the Standard Dose The 1000 mcg dose is chosen for its quick fix of vitamin B12

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Those with significant fat loss goals Individuals with 50+ pounds to lose may benefit from extended protocols with strategic breaks rather than aggressive dosing

Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss