In CD4 T helper cells, the 1,25(OH)DVDR axis suppresses Th1/Th17-associated cytokines such as IFN-, IL-17 A, and IL-22, while upregulating Th2-related cytokines including IL-4, IL-5, and IL-13, thus promoting a functional shift toward Th2 polarization [163,164,165]
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Cardiovascular or respiratory disease, renal or hepatic impairment, diabetes, Helicobacter pylori infection, rheumatoid arthritis, and hypertension are also associated with increased risk
Sandhu MS, Heald AH, Gibson JM, Cruickshank JK, Dunger DB, Wareham NJ
Chen L-Y, Kang Y-N, Hoang KD, Chen K-H, Chen C
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