Several key gene modifications related to silencing specific genes or introducing exogenous genes into the HSV-1 genome will be discussed separately
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Emerging solutions include encapsulating ferroptosis inhibitors in long-circulating liposomes or polymeric nanoparticles to prolong circulation and enhance myocardial deposition [376], as well as designing more stable analogues with improved pharmacokinetic profiles [375]
Two major lipid peroxidation products, malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), increase with aging and contribute to the pathogenesis of AMD 63,64,65