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The medication enhances browning in adipose tissues

2019 Oct;165:250-257

In an imiquimod-induced PsOs-like mouse model, oral administration of proanthocyanidins significantly alleviated skin lesions, reduced epidermal hyperplasia, and decreased inflammatory cell infiltration

Sigstad H

Insulin also suppresses glucagon secretion from pancreatic -cells [6,7] and reduces appetite via the central nervous system