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Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women

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These data suggest that EPACs are induced early in melanomagenesis and contribute to primary tumor growth by regulation of redox homeostasis, mitochondrial ROS, and glycolytic metabolism through activation of mTORC1-HIF-1-TXNIP signaling