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MECHANISM CATEGORIES SAFETY Side effects GI: nausea, vomiting, diarrhea Injection-site reactions Known interactions Class effect sulfonylureas/insulin Contraindications History of MTC or MEN2 REGULATORY STATUS FDA Investigational outside China

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At another level, GLP-1RAs also improve systemic insulin sensitivity to lower arterial hypertension in T2DM by decreasing the concentration of angiotensin II (Ang II) [41, 42]

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Abstract Background Coronary artery disease (CAD) persists as a major global health burden, contributing significantly to both morbidity and mortality rates worldwide, mostly attributable to atherosclerosis and oxidative stress

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