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Individuals with SMIs experience premature and excess mortality, with years of life lost often estimated between 5 and 25 years, largely due to earlier onset and substantially higher rates of CVD

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Yet, the potential of such approaches may be contingent upon individual variations in MC1R function and expression, highlighting the need for further research to fully understand and leverage MC1R's protective mechanisms in skin cells

10.1016/0300-483X(89)90076-0 8

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