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We have noted this before with exenatide, liraglutide and semaglutide (Neumann et al

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Thus, receptors with the intracellular domain of IGF1R showed increased activation of Shc and Gab-1 and more potent regulation of genes involved in proliferation, whereas those with the intracellular domain of IR showed higher IRS-1 phosphorylation and stronger regulation of genes involved in metabolic pathways (14)